Matches in SemOpenAlex for { <https://semopenalex.org/work/W2383901880> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2383901880 abstract "Objective To investigate the effects of paclitaxel on the quantitative proliferation and migration of rabbit vascular smooth muscle cells (SMC) and endothelial cells (EC). Methods In the cell coculture system, rabbit EC were seeded on the lower chamber and SMC on the upper chamber. 3H-TdR incorporation and proliferating cell nuclear antigen ( PCNA ) protein expression were used and migration rate was analyzed to determine the effects of paclitaxel on the migration of rabbit vascular EC and SMC. The IC50 of paclitaxel on EC and SMC was calculated. Results The 3H-TdR incorporation, PCNA protein expression and cell migration rate of SMC were inhibited by paclitaxel between 1 nmol/L and 1 μmol/L in a concentration-dependent manner( n = 6, P 0. 05 ) ; those of EC were also inhibited by paclitaxel between 10 nmol/L and 1μmol/L in a concentration-dependent manner (n =6, P 0. 05) ; the 3H-TdR incorporation and PCNA protein expression of EC were not inhibited by paclitaxel of 1 nmol/L, but the migration of EC was inhibited significantly by paclitaxel of 1 nmol/L (n = 6, P 0. 05 ) . The IC50 of paclitaxel on the proliferation and migration of rabbit vascular SMC was (10. 09±0. 47) nmol/L and (9. 16±0. 54) nmol/L respectively. The IC50 of paclitaxel on the proliferation and migration of rabbit vascular EC respectively were (19. 05 ±0. 35) nmol/L and (5. 37 ±0. 51) nmol/L. Conclusion Paclitaxel could inhibit the proliferation and migration of rabbit vascular SMC and EC , delay EC regeneration in a concentration-dependent manner." @default.
- W2383901880 created "2016-06-24" @default.
- W2383901880 creator A5035847286 @default.
- W2383901880 date "2004-01-01" @default.
- W2383901880 modified "2023-09-24" @default.
- W2383901880 title "Effects of paclitaxel on the quantitative proliferation and migration of rabbit vascular smooth muscle cells and endothelial cells" @default.
- W2383901880 hasPublicationYear "2004" @default.
- W2383901880 type Work @default.
- W2383901880 sameAs 2383901880 @default.
- W2383901880 citedByCount "0" @default.
- W2383901880 crossrefType "journal-article" @default.
- W2383901880 hasAuthorship W2383901880A5035847286 @default.
- W2383901880 hasConcept C126322002 @default.
- W2383901880 hasConcept C134018914 @default.
- W2383901880 hasConcept C137738243 @default.
- W2383901880 hasConcept C1491633281 @default.
- W2383901880 hasConcept C153911025 @default.
- W2383901880 hasConcept C185592680 @default.
- W2383901880 hasConcept C202751555 @default.
- W2383901880 hasConcept C2776694085 @default.
- W2383901880 hasConcept C2777292972 @default.
- W2383901880 hasConcept C2777752497 @default.
- W2383901880 hasConcept C2779395532 @default.
- W2383901880 hasConcept C2992686903 @default.
- W2383901880 hasConcept C34688535 @default.
- W2383901880 hasConcept C55493867 @default.
- W2383901880 hasConcept C62112901 @default.
- W2383901880 hasConcept C71924100 @default.
- W2383901880 hasConcept C86803240 @default.
- W2383901880 hasConcept C98274493 @default.
- W2383901880 hasConceptScore W2383901880C126322002 @default.
- W2383901880 hasConceptScore W2383901880C134018914 @default.
- W2383901880 hasConceptScore W2383901880C137738243 @default.
- W2383901880 hasConceptScore W2383901880C1491633281 @default.
- W2383901880 hasConceptScore W2383901880C153911025 @default.
- W2383901880 hasConceptScore W2383901880C185592680 @default.
- W2383901880 hasConceptScore W2383901880C202751555 @default.
- W2383901880 hasConceptScore W2383901880C2776694085 @default.
- W2383901880 hasConceptScore W2383901880C2777292972 @default.
- W2383901880 hasConceptScore W2383901880C2777752497 @default.
- W2383901880 hasConceptScore W2383901880C2779395532 @default.
- W2383901880 hasConceptScore W2383901880C2992686903 @default.
- W2383901880 hasConceptScore W2383901880C34688535 @default.
- W2383901880 hasConceptScore W2383901880C55493867 @default.
- W2383901880 hasConceptScore W2383901880C62112901 @default.
- W2383901880 hasConceptScore W2383901880C71924100 @default.
- W2383901880 hasConceptScore W2383901880C86803240 @default.
- W2383901880 hasConceptScore W2383901880C98274493 @default.
- W2383901880 hasLocation W23839018801 @default.
- W2383901880 hasOpenAccess W2383901880 @default.
- W2383901880 hasPrimaryLocation W23839018801 @default.
- W2383901880 hasRelatedWork W1598104848 @default.
- W2383901880 hasRelatedWork W1993275120 @default.
- W2383901880 hasRelatedWork W1998561343 @default.
- W2383901880 hasRelatedWork W2056444478 @default.
- W2383901880 hasRelatedWork W2059933674 @default.
- W2383901880 hasRelatedWork W2062313250 @default.
- W2383901880 hasRelatedWork W2071861204 @default.
- W2383901880 hasRelatedWork W2266882949 @default.
- W2383901880 hasRelatedWork W2349382705 @default.
- W2383901880 hasRelatedWork W2351598619 @default.
- W2383901880 hasRelatedWork W2365244765 @default.
- W2383901880 hasRelatedWork W2369516964 @default.
- W2383901880 hasRelatedWork W2376753611 @default.
- W2383901880 hasRelatedWork W2376764083 @default.
- W2383901880 hasRelatedWork W2380844964 @default.
- W2383901880 hasRelatedWork W2382418333 @default.
- W2383901880 hasRelatedWork W2399769026 @default.
- W2383901880 hasRelatedWork W2412750463 @default.
- W2383901880 hasRelatedWork W2978926718 @default.
- W2383901880 hasRelatedWork W2066822729 @default.
- W2383901880 isParatext "false" @default.
- W2383901880 isRetracted "false" @default.
- W2383901880 magId "2383901880" @default.
- W2383901880 workType "article" @default.