Matches in SemOpenAlex for { <https://semopenalex.org/work/W2383906935> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2383906935 abstract "Objective To investigate the protective effect of hemeoxygenase-1(HO-1) and its metabolite bilirubin induced by quercetin on ethanol-induced oxidative damage in hepatocytes.Methods Primary hepatocytes were isolated from Sprague-Dawley rat using two-step collagenase perfusion technique.The oxidative damage model was established through ethanol(200 mmol/L) incubation for 24 h.Meanwhile,the ethanol-intoxicated hepatocytes were treated with quercetin(100 μmol/L),hemin(20 μmol/L) or different dose of bilirubin(2-100 μmol/L),etc.The activities of superoxide dismutase(SOD),as well as the levels of malondialdehyde(MDA),glutathione(GSH),total bilirubin and reactive oxygen species(ROS) were detected following 24 h incubation.Results Quercetin inhibited the increase of MDA and ROS,the GSH depletion and SOD inactivation in heaptocytes induced by ethanol.Exogenous bilirubin,however,manifested the similar protective effect in dose-dependent manner to some extent.Znpp-IX,HO-1 inhibitor,abolished the protective effect of quercetin.Conclusion Quercetin prevented rat primary hepatocytes from ethnol-induced oxidative damage through the effect of bilirubin,one of the HO-1 metabolites." @default.
- W2383906935 created "2016-06-24" @default.
- W2383906935 creator A5019797064 @default.
- W2383906935 date "2010-01-01" @default.
- W2383906935 modified "2023-09-23" @default.
- W2383906935 title "THE MEDIATE EFFECT OF BILIRUBIN INVOLVED IN QUERCETIN AGAINST ETHANOL-INDUCED HEPATOCYTES INJURY" @default.
- W2383906935 hasPublicationYear "2010" @default.
- W2383906935 type Work @default.
- W2383906935 sameAs 2383906935 @default.
- W2383906935 citedByCount "0" @default.
- W2383906935 crossrefType "journal-article" @default.
- W2383906935 hasAuthorship W2383906935A5019797064 @default.
- W2383906935 hasConcept C134018914 @default.
- W2383906935 hasConcept C181199279 @default.
- W2383906935 hasConcept C185592680 @default.
- W2383906935 hasConcept C25642318 @default.
- W2383906935 hasConcept C2775838275 @default.
- W2383906935 hasConcept C2776151105 @default.
- W2383906935 hasConcept C2777513400 @default.
- W2383906935 hasConcept C2778004101 @default.
- W2383906935 hasConcept C2778401633 @default.
- W2383906935 hasConcept C2780161600 @default.
- W2383906935 hasConcept C2781263971 @default.
- W2383906935 hasConcept C48349386 @default.
- W2383906935 hasConcept C538909803 @default.
- W2383906935 hasConcept C55493867 @default.
- W2383906935 hasConcept C86803240 @default.
- W2383906935 hasConcept C98274493 @default.
- W2383906935 hasConceptScore W2383906935C134018914 @default.
- W2383906935 hasConceptScore W2383906935C181199279 @default.
- W2383906935 hasConceptScore W2383906935C185592680 @default.
- W2383906935 hasConceptScore W2383906935C25642318 @default.
- W2383906935 hasConceptScore W2383906935C2775838275 @default.
- W2383906935 hasConceptScore W2383906935C2776151105 @default.
- W2383906935 hasConceptScore W2383906935C2777513400 @default.
- W2383906935 hasConceptScore W2383906935C2778004101 @default.
- W2383906935 hasConceptScore W2383906935C2778401633 @default.
- W2383906935 hasConceptScore W2383906935C2780161600 @default.
- W2383906935 hasConceptScore W2383906935C2781263971 @default.
- W2383906935 hasConceptScore W2383906935C48349386 @default.
- W2383906935 hasConceptScore W2383906935C538909803 @default.
- W2383906935 hasConceptScore W2383906935C55493867 @default.
- W2383906935 hasConceptScore W2383906935C86803240 @default.
- W2383906935 hasConceptScore W2383906935C98274493 @default.
- W2383906935 hasOpenAccess W2383906935 @default.
- W2383906935 hasRelatedWork W1978589242 @default.
- W2383906935 hasRelatedWork W1981388447 @default.
- W2383906935 hasRelatedWork W1994105710 @default.
- W2383906935 hasRelatedWork W2019168323 @default.
- W2383906935 hasRelatedWork W2029186842 @default.
- W2383906935 hasRelatedWork W2030834862 @default.
- W2383906935 hasRelatedWork W2033618502 @default.
- W2383906935 hasRelatedWork W2043102560 @default.
- W2383906935 hasRelatedWork W2045577612 @default.
- W2383906935 hasRelatedWork W2052170653 @default.
- W2383906935 hasRelatedWork W2145594175 @default.
- W2383906935 hasRelatedWork W2270565676 @default.
- W2383906935 hasRelatedWork W2415316149 @default.
- W2383906935 hasRelatedWork W2777589160 @default.
- W2383906935 hasRelatedWork W2988546173 @default.
- W2383906935 hasRelatedWork W3012398221 @default.
- W2383906935 hasRelatedWork W3042421931 @default.
- W2383906935 hasRelatedWork W3097616519 @default.
- W2383906935 hasRelatedWork W3143695985 @default.
- W2383906935 hasRelatedWork W2740735257 @default.
- W2383906935 isParatext "false" @default.
- W2383906935 isRetracted "false" @default.
- W2383906935 magId "2383906935" @default.
- W2383906935 workType "article" @default.