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- W2383909009 abstract "Objective Engineer heart tissue(EHT)was constructed with mesenchymal stem cells(MSCs)and poly lacticacid-CO-glycolic acid(PLGA),and grafted onto the surface of myocardial infarction rats.We hypothesized that great omentum wrapping would increase EHT blood supply and ameliorate EHT microenvironment which is in favor of cardiac collagen remodling and heart function.We hope that omentun wrapped EHT could provide a valuable strategy for surgically myocardial infarction therapy.Methods MSCs were isolated from SD rats.Eight weeks after SD rats were subjected to left anterior descending(LAD)ligation,18 rats were enrolled and divided into three groups,group A(n=6):great omentum wrapped MSCs-PLGA EHT implantation;group B(n=6):MSCs-PLGA EHT implantation;control group(n=6):the myocardial infarction;the sham group(n=6):only opened and closed chest,underwent LAD ligation,but no EHT implantation.Four weeks after transplantation,the following variables were evaluated:specimen stained with picrosirius red,left ventricle function evaluated by echocardiography,infarction ventricular wall motion by color kinesis(CK).Results Hearts of group A showed significantly less fibrosis than group B and control group(P0.05).Infarction ventricular wall motion assessed by CK indicated significantly improvement in group A compared with group B and control group(P0.05).Four weeks after transplantation,cardiac echocardiography showed left ventricle ejection fraction was lower in control group and group B compared with group A(P0.05).Conclusion Transplantation of MSCs-PLGA EHT with great omentum wrapping ameliorated infarction ventricular collagen remodeling,ameliorated infarction ventricular wall motion and preserved left ventricular function." @default.
- W2383909009 created "2016-06-24" @default.
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- W2383909009 date "2008-01-01" @default.
- W2383909009 modified "2023-09-24" @default.
- W2383909009 title "Great Omentum Wrapped Engineer Heart Tissue Transplantation Preserves Cardiac Function in Myocardial Infarction Rats" @default.
- W2383909009 hasPublicationYear "2008" @default.
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