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- W2383943801 abstract "Objective:To investigate the role of effects of growth hormone (GH) on tissue repair in the acid induced acute lung injury(ALI) in rats.Methods:A model of acidinduced lung injury in rats was established. Eightyfour healthy Wistar rats were randomly divided into three groups:control group(NS group),hydrochloric acid group (HCl group),hydrochloric acid injury and growth hormone group (GH group).TdTmediated dUTP nick end labeling(TUNEL) method was used to observe apoptosis in lung tissues. The plasma levels of tumor necrosis factorα(TNFα),interleukin8(IL8),insulinlike growth factor(IGF1) in rats were measured by immunoassay. Results:Hydrochloric acid inspiration leads to visible lung injury,and the rapid appearance of apoptosis occurred in lung tissue in rats.The plasma levels of TNFα,IL8,IGF1 were increased at the early stage of ALI.A half hour after the instillation of HCl,TNFα and IL8 levels were measured to be (2 17± 0 41) μg/L ,(0 91±0 08) μg/L in HCl group and (3 14± 0 28) μg/L, (0 68±0 19) μg/L in GH group, respectively ,and the differences were significant ( P 0 05 or P 0 01 ).The level of IGF1 in GH group was higher than that in HCl group 〔(128 36±30 56) μg/L vs.(14 19±7 89) μg/L, P 0 05〕,while the apoptosis rate of lung tissue in GH group was lower than that in HCl group 〔(16 83±3 03)% vs.(20 89±1 36)%, P 0 05〕. Conclusions: Cell apoptosis is a common phenomenon in hydrochloric acidinduced lung injury in rats.The TNFα and IL8 may play a role in the pathogenesis of this animal model.The increased plasma IGF1 level with a less apoptosis rate of lung cells were supposed to be helpful for tissue repair in this acidinduced lung injury model.In other words,GH has an obvious antiapoptosis effect on rat's lung cells in vivo in our experiment." @default.
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- W2383943801 date "2002-01-01" @default.
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- W2383943801 title "Effects of growth hormone on apoptosis in the acid-induced lung injury in rats" @default.
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