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- W2383977766 abstract "Objective To observe the changes of levels of nerve growth factor(NGF) during bone healing in fracture combined with traumatic brain injury,and to investigate its effect during the process in order to deepen the understanding for bone physiology,and to provide a theoretical basis for intervention of bone healing.Methods 72 rats were randomly divided into normal control group(group N,n=6),traumatic brain injury group(TBI group,n=6),fracture group(group F,n=30),fracture combined with brain trauma group(TBI+F group,n=30).The models of traumatic brain injury in SD rats were established,and histological observation and ELISA were used to observe the changes of NGF levels in serum during fracture combined with brain trauma.Results The serum OD value in NGF group was 0.041,the levels of serum NGF in group F were slightly increased at 3 days after surgery,which would reach peak at one week after surgery,then which gradually decreased and reached normal levels on the 4th week.The NGF levels in TBI group and TBI+F group at 3 days after surgery increased obviously,which began to decrease at one week after surgery and reached normal levels on the 5th week,there were significant differences in the NGF levels between TBI+F group and TBI group or group F(P0.05).Conclusion NGF may play an important role in promoting bone." @default.
- W2383977766 created "2016-06-24" @default.
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- W2383977766 date "2009-01-01" @default.
- W2383977766 modified "2023-09-26" @default.
- W2383977766 title "The role of NGF during bone healing in fracture combined with traumatic brain injury" @default.
- W2383977766 hasPublicationYear "2009" @default.
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