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- W2383984037 abstract "The present study was designed to investigate the effects of bovine adrenal medulla 8-22(BAM8-22),an selective agonist of sensory neuron-specific receptor(SNSR),on morphine tolerance in formalin-induced persistent pain.Intrathecal(i.t.) administration of morphine(20 μg) markedly inhibited formalin-evoked lifting / licking and flinching behaviors in naive rats,but this inhibition effect remarkably lower in morphine tolerance when morphine was administrated i.t.for 7 days(P 0.001).Pretreatment i.t.with BAM8-22(0.1 nmol) evidently reversed established morphine tolerance.Formalin-induced the time of lifting / licking and the number of flinches were respectively decrease 39.4%(P 0.001) and 25.3%(P 0.05) in second phase in formalin test,compared with morphine in tolerant rats.Co-administration of BAM8-22(0.1 nmol) daily with morphine did not inhibit the development of morphine tolerance,but Co-administration of BAM8-22(0.1 nmol) every other day,but not daily,with morphine remarkably attenuated the development of morphine tolerance.The time of lifting / licking and the number of flinches were respectively decrease 41.0%(P 0.001) and 24.8%(P 0.05) in second phase compared with morphine in tolerant rats.However,i.t.BAM8-22 did not completely reverse or inhibit morphine tolerance in formalin test.Moreover,antinociception of morphine were significantly weakened after repeated daily treat-ments with BAM8-22.These results suggested that SNSR may be able to modulate the sensitivity of opioid receptor in persistent pain.This study also demonstrated that using BAM8-22 to attenuate or reverse morphine tolerance may be a better regimen for long-term use of opioids to treat persistent pain." @default.
- W2383984037 created "2016-06-24" @default.
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- W2383984037 date "2013-01-01" @default.
- W2383984037 modified "2023-09-28" @default.
- W2383984037 title "The Modulation Effect of Bovine Adrenal Medulla 8-22 on Morphine Tolerance in Formalin-induced Persistent Pain" @default.
- W2383984037 hasPublicationYear "2013" @default.
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