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- W2383996927 abstract "Objective To investigate the correlation of the MMP9 SNPs with genetic susceptibility and development of NPC. Methods The MMP9 C-1562T and exon 6 R279Q genotypes in 433 NPC patients and 437 controls from a Guangdong population using PCR-RFLP were analyzed, and also studied the association between the genotypes and clinicopathologi- cal features among cases. Results Smoking significantly increased the risk of NPC development(OR = 4.01, 95% CI = 2.86- 5.63). The distribution of C-1562T and R279Q genotypes was not significantly associated with the risk of NPC(OR = 0.99, 95% CI = 0.70-1.39 for-1562 CT / TT genotypes versus CC genotype; OR = 0.96, 95% CI = 0.70-1.32 for 279 RQ / QQ genotypes versus RR genotype), neither the genotypes combination. When stratified by smoking status, SNPs did not show any significant in- fluence on the risk of NPC development. No significant association was found between clinicopathological features and the two poly- morphisms in NPC patients. Conclusion MMP9 gene C-1562T and exon6 R279Q polymorphisms may be not a genetic susceptibili- ty factor to NPC in Guangdong population." @default.
- W2383996927 created "2016-06-24" @default.
- W2383996927 creator A5091546442 @default.
- W2383996927 date "2013-01-01" @default.
- W2383996927 modified "2023-09-27" @default.
- W2383996927 title "Relationship between MMP9 gene polymorphisms and genetic susceptibility in nasopharyngeal carcinoma" @default.
- W2383996927 hasPublicationYear "2013" @default.
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