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- W2384001054 abstract "Objective:To study the characteristics of CD4+ T cells TCR Vβ gene clonning in hepatitis B vaccinated and the difference of TCR Vβ genes monoclonal changes between the clone of genes in responders and non responders to hepatitis B vaccine.Methods:CD4+ T cells of 80 hepatitis B vaccinated individual Vβ genes CDR3 region fragments were amplified by multi-primer PCR amplification methods,PCR products were aplied on agarose gel electrophoresis and gene scanning by sequencing instrument.Results:From 80 cases of hepatitis B vaccinated individual,58 cases were positive for anti-HBs and 22 cases were negative.Monoclonal TCR Vβ gene changes were mainly concentrated in Vβ2,Vβ8,Vβ9,Vβ11,and Vβ17 family of genes.The frequency of changes in these five family of genes was significantly lower in nonresponders group than responders(P0.01 or P0.05).Conclusion:CD4+ T cells of TCR Vβ gene change is one of the important factor that affect the body's immune response to hepatitis B vaccine." @default.
- W2384001054 created "2016-06-24" @default.
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- W2384001054 date "2011-01-01" @default.
- W2384001054 modified "2023-09-25" @default.
- W2384001054 title "Analysis of CD4~+T cell TCR gene in non responders for hepatitis B vaccine" @default.
- W2384001054 hasPublicationYear "2011" @default.
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