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- W2384013876 abstract "Objective To explore the influence of two kinds of various treatment plans on long-term remission by short-term intensive insulin therapy in newly diagnosed type 2 diabetes mellitus(T2DM) patients. Methods A total of 84 inpatients with newly diagnosed T2DM who had a two-week course of insulin therapy were randomly assigned to two groups,the first group of administrated metformin agent(MET group)and the second group of administrated insulin-sensitizer agent(TZD group).Subjects were then followed at least one year,and possible differences of two treatment plans on long-term remission were observed. Results ①At one year in follow-up,the remission rate was 66.7%(28/42) in MET group,and the remission rate was 71.4%(30/42)in TZD group.The remission rate was no statistic siginificance between MET group and TZD group(χ2=0.22,P0.05).②At the end of one year's follow-up,the value of Homeostasis Model Assessment of Insulin Resistance(HOMA-IR) was significantly lower,1.14±0.22 vs 1.46±0.25,and the value of the ratio of insulin from 0 to 30 min to glucose from 0 to 30 mintes(△I30/△G30),the increment of HOMA-IR,△I30/△G30(value of the end of one year follow-up minus that of stopping intensive therapy) were all significantly higher in TZD remission group,as compared with MET remission group,2.61±0.29 vs 2.08±0.33(P0.01). Conclusion As sooner administrating metformin agent or insulin-sensitizer agent after the short-term intensive insulin treatment in newly diagnosed T2DM patients can induce a relatively long term remission of diabetes mellitus.Insulin-sensitizer agent might better improve the shortage of pathophisiology of T2DM compared with metformin agent." @default.
- W2384013876 created "2016-06-24" @default.
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- W2384013876 date "2011-01-01" @default.
- W2384013876 modified "2023-09-28" @default.
- W2384013876 title "Influence of two kinds of various treatment plans on long-term remission by short-term intensive insulin therapy in newly diagnosed type 2 diabetes mellitus patients" @default.
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