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- W2384014748 abstract "Background and aims Previously We have documented that lung injury after trauma-hemorrhagic shock (T/HS) is significant 3 hours after resuscitation and that females are more resistant to T/HS-induced lung injury than males. However, it is not known if the lung injury and its gender dimorphrism still exsit 5 days after resuscitation. Therefore, We aim to determine the lung injury after T/HS and to compare its gender difference 5 days after resuscitation. Methods Male and female Sprague-Dawley rats were subjected to a midline laparotomy (trauma) and either hemorrhagic shock or sham shock. At the end of the shock period, the animals were resuscitated with Ringer lactate 3 times of their shed blood. Five days postresuscitation, the animals were sacrificed and lung permeability was measured . Results Lung permeability and pulmonary leukosequestration in T/HS animals were increased significantly 5 days In contrast to what seen 3 hours post-resuscitation, lung injury of female animals were more severe than male. That is, Females subjected to T/HS had increased pulmonary permeability, increased BALF protein/plasma protein ratio and increased pulmonary myeloperoxidase levels than males. Males gained while females lost body weight during study period. Conclusion Lung injury still can be seen 5 days aftar resuscitation. The injury is more severe in female than in male." @default.
- W2384014748 created "2016-06-24" @default.
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- W2384014748 date "2007-01-01" @default.
- W2384014748 modified "2023-09-28" @default.
- W2384014748 title "Gender dimorphism in lung injury after trauma/hemorrhagic shock" @default.
- W2384014748 hasPublicationYear "2007" @default.
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