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- W2384018082 abstract "Objective:To study effects of probiotic L Casei Zhang on the NO / iNOS expression in macrophage cell line RAW264.7and explore related mechanisms.;1X10~6CFU probiotic L Casei Zhang co- cultured RAW264.7 cells for 2h,6h,12 h and 24 h.Cell culture supematants were collected.The production of NO was measured.The mRNA levels of iNOS、TLR2 and TLR4 were measured by Real- rime PCR.RAW264.7 cells were pretreated with L Casei Zhang for 3h,and then stimulated with LPS,CpG,and Polyl;C.NO and iNOS expression were measured accordingly.Results:Probiotic L Casei Zhang promoted NO secretion and iNOS expression in RAW264.7 cells.Compared with the baseline expression of TLR2 mRNA,L Casei Zhang increased TLR2 mRNA levels in RAW264.7 cells.TLR4 mRNA levels were significantly higher after L Casei Zhang treated RAW264.7 cells for 2h.The levels of NO / iNOS expression declined in LPS and Polyl;C- activated cells pretreatment with L Casei Zhang.Conclusion;The stimulatory effects of Lactobacillus Casei on the expression of NO / iNOS in macrophages are related with increased expression of TLR2 and TLR4 mRNA.L Casei Zhang significantly suppressed LPS and Polyl;C- induced NO / iNOS expression in RAW264.7 macrophages.This study may lay a foundation for further elucidating the immunomodulatory effects of probiotics." @default.
- W2384018082 created "2016-06-24" @default.
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- W2384018082 date "2014-01-01" @default.
- W2384018082 modified "2023-09-28" @default.
- W2384018082 title "EFFECTS OF PROBIOTIC Lactobacillus casei Zhang ON THE EXPRESSION OF iNOS/NO IN RAW264.7CELLS AND RELATED MECHANISMS" @default.
- W2384018082 hasPublicationYear "2014" @default.
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