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- W2384018991 abstract "Objective:To explore the long-term effects of physical exercises on penicillin induced recurrent convulsion with learning and memory deficits in developing rats and its mechanism. Method:Fifty-six male SD rats (postnatal days [PD] 21) were randomly divided into four groups: control group (CONT1), control plus exercises group(CONT2), convulsion group(EXP1) and convulsion plus exercises group(EXP2). Twenty rats were assigned for two control groups, each n=10; the surplus 36 rats were kindled by penicillin once per d, consecutive 6d for creating convulsion models. Control rats were injected equal amount of normal sodium(NS) into abdominal cavity at the same time. The 20 qualified models of convulsion rats were randomly divided into two EXP groups. On PD39-PD43 and PD61-PD64, subjects of the four groups were tested with Morris water maze, and from PD49 to PD54, the rats of CONT2 and EXP2 were given exercises of running wheels, twice a d for consecutive 6d. The expression of glutamicacid receptor 2(GluR2) in hippocampus was detected. Result: ①In the first Morris water maze test, there were significant differences of latency among four groups (F= 5.56, P0.01), and the latency of two EXP groups were significantly longer than two CONT groups (P0.05); In the probe trial, the frequency of two EXP groups passing through target area were significantly less than that of two CONT groups. ②In the second water maze test, there were significant effects of exercises on the latency of EXP2 group comparing to EXP1 group (P0.05); the frequency of two EXP groups passing through target area were still significantly less than that of two CONT groups after exercises training (P 0.05),and there was no significant difference between EXP1 and EXP2 groups. ③In the immunohistochemical staining of GluR2, the gray values in hipocampus of two convulsion groups were significantly lower than that of two control groups(P0.05). Conclusion: Penicillin induced recurrent convulsion could cause long-term effects on learning and memory in rats, which may be associated with down-regulated GluR2 expression in hippocampus. Physical exercises could improve learning capacity, of convulsion rats but not memory capacity." @default.
- W2384018991 created "2016-06-24" @default.
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- W2384018991 date "2010-01-01" @default.
- W2384018991 modified "2023-09-28" @default.
- W2384018991 title "The long-term effects of physical exercises on recurrent convulsion-induced cognitive deficits in developing rats and it′s mechanism" @default.
- W2384018991 hasPublicationYear "2010" @default.
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