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- W2384027400 abstract "Objective To test the effect of intravenously injected human bone marrow stromal cells(hMSCs) on neurological funtional deficits after stroke in rats.Methods Methods hMSCs got from healthy people were propagated.Rats were subjected to transient middle cerebral artery occlusion and intravenously injected with 3×10 6hMSCs 1 day later after stroke.Functional outcome was measured before andat 1,7,14,28 days after stroke.Neurotrophin levels in cerebral tissue with or without hMSC treatment were analyzed by ELISA.Apoptosis cells in the ischemic hemisphere were analyzed by flowcytometer.Immunohistochemistry was used to identify hMSCs and cells derived from hMSCs in brain. Results Significant recovery of neurological function was found in rats treated with hMSCs at 7,14,21,28 days compared to controlled ischemia rats.Brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) significant increased,and apoptotic cells significantly decreased in the ischemic hemisphere.With immunohistochemistry examination hMSCs could be found in brain,and a few hMSCs expressed proteins phenotypic of brain parenchymal cells. Conclusions Intravenous injected hMSCs is simple and effective on improvement of neurological functional deficits after stroke in rats. The increase of growth factors in the ischemic tissue play an important role in neurological recovery." @default.
- W2384027400 created "2016-06-24" @default.
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- W2384027400 date "2002-01-01" @default.
- W2384027400 modified "2023-09-28" @default.
- W2384027400 title "The experimental research of applying human bone marrow stromal cells to treat brain ischemia rat" @default.
- W2384027400 hasPublicationYear "2002" @default.
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