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- W2384044186 abstract "Objective:To investigate the effects of YN-3 on changes of NR2A NR2B mRNA in hippocampal tissue in chronic stress rats. Method:Thirty-two male SD rats were evenly randomized into control,stress-model,and YN-3 group and Prozac220 group. Chronic stress model was established by using mixed stimulation. The contents of corticosterone (CORT) and Glutamic acid(Glu) in hippocampal tissue were detected with radioimmunoassay techniques and electro-chemical detection technique. NR2A,NR2BmRNA expressions in hippocampal tissue by Quantitative Real Time PCR.Result:Compared with control group,the rats′ hippocampal NR2A and NR2BmRNA contents increased remarkably in model group(P0.01). In comparison with control group,the rats′ NR2A,NR2BmRNA contents lowered significantly in YN-3 group(P0.05). Conclusion:Chronic stress may cause high level NR2A and NR2BmRNA in hippocampal,whereas YN-3 can adjust the expression of NR2A and NR2BmRNA in hippocampal tissue." @default.
- W2384044186 created "2016-06-24" @default.
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- W2384044186 date "2008-01-01" @default.
- W2384044186 modified "2023-09-25" @default.
- W2384044186 title "Effects of YN-3 on NR2A,NR2B mRNA expressions in hippocampal tissue in chronic stress model rats" @default.
- W2384044186 hasPublicationYear "2008" @default.
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