Matches in SemOpenAlex for { <https://semopenalex.org/work/W2384045770> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2384045770 abstract "【Objective】 To investigate the role and mechanism of the antioxidant pyrrolidine dithiocarbamate(PDTC) in the chemoprevention of hepatocellular carcinoma(HCC).【Methods】 MTT assay was used to determine the effect of PDTC and cisplatin in single or in combination on the proliferation of HepG2.Flow cytometry was used to observe the effect of different concentrations of PDTC on DNA level of HepG2 cell.The effect on the expression levels of NF-κBp65 mRNA and NF-κBp65 protein in HepG2 cells was detected by RT-PCR and Western blotting.【Results】 PDTC and cisplatin in single or in combination inhibited the proliferation of HepG2 cells in a dose-dependent manner.PDTC and cisplatin in combination enhanced the effect of prolifereation inhibition compared with cisplatin in single.PDTC also induced cell arrest of HepG2 cells.The protein level of NF-κBp65 in nucleus was significantly decreased in HepG2 cells after PDTC treatment,but the mRNA level of NF-κBp65 was not significantly changed in HepG2 cells after PDTC treatment.【Conclusion】 PDTC inhibits proliferation,enhances the cytotoxicity of cisplatin and induces cell arrest of HepG2 cells.The mechanism is mainly due to prevention of NF-κBp65 into nucleus in HepG2." @default.
- W2384045770 created "2016-06-24" @default.
- W2384045770 creator A5053811566 @default.
- W2384045770 date "2012-01-01" @default.
- W2384045770 modified "2023-09-24" @default.
- W2384045770 title "Effect of PDTC on proliferation of human hepatocellular carcinoma cell line HepG2 and its mechanism" @default.
- W2384045770 hasPublicationYear "2012" @default.
- W2384045770 type Work @default.
- W2384045770 sameAs 2384045770 @default.
- W2384045770 citedByCount "0" @default.
- W2384045770 crossrefType "journal-article" @default.
- W2384045770 hasAuthorship W2384045770A5053811566 @default.
- W2384045770 hasConcept C104317684 @default.
- W2384045770 hasConcept C109316439 @default.
- W2384045770 hasConcept C126322002 @default.
- W2384045770 hasConcept C1491633281 @default.
- W2384045770 hasConcept C153911025 @default.
- W2384045770 hasConcept C185592680 @default.
- W2384045770 hasConcept C190283241 @default.
- W2384045770 hasConcept C202751555 @default.
- W2384045770 hasConcept C2776694085 @default.
- W2384045770 hasConcept C2777730290 @default.
- W2384045770 hasConcept C2778019345 @default.
- W2384045770 hasConcept C2778239845 @default.
- W2384045770 hasConcept C2780783641 @default.
- W2384045770 hasConcept C2780983412 @default.
- W2384045770 hasConcept C502942594 @default.
- W2384045770 hasConcept C54355233 @default.
- W2384045770 hasConcept C553184892 @default.
- W2384045770 hasConcept C55493867 @default.
- W2384045770 hasConcept C62112901 @default.
- W2384045770 hasConcept C71924100 @default.
- W2384045770 hasConcept C81885089 @default.
- W2384045770 hasConcept C85265743 @default.
- W2384045770 hasConcept C86803240 @default.
- W2384045770 hasConceptScore W2384045770C104317684 @default.
- W2384045770 hasConceptScore W2384045770C109316439 @default.
- W2384045770 hasConceptScore W2384045770C126322002 @default.
- W2384045770 hasConceptScore W2384045770C1491633281 @default.
- W2384045770 hasConceptScore W2384045770C153911025 @default.
- W2384045770 hasConceptScore W2384045770C185592680 @default.
- W2384045770 hasConceptScore W2384045770C190283241 @default.
- W2384045770 hasConceptScore W2384045770C202751555 @default.
- W2384045770 hasConceptScore W2384045770C2776694085 @default.
- W2384045770 hasConceptScore W2384045770C2777730290 @default.
- W2384045770 hasConceptScore W2384045770C2778019345 @default.
- W2384045770 hasConceptScore W2384045770C2778239845 @default.
- W2384045770 hasConceptScore W2384045770C2780783641 @default.
- W2384045770 hasConceptScore W2384045770C2780983412 @default.
- W2384045770 hasConceptScore W2384045770C502942594 @default.
- W2384045770 hasConceptScore W2384045770C54355233 @default.
- W2384045770 hasConceptScore W2384045770C553184892 @default.
- W2384045770 hasConceptScore W2384045770C55493867 @default.
- W2384045770 hasConceptScore W2384045770C62112901 @default.
- W2384045770 hasConceptScore W2384045770C71924100 @default.
- W2384045770 hasConceptScore W2384045770C81885089 @default.
- W2384045770 hasConceptScore W2384045770C85265743 @default.
- W2384045770 hasConceptScore W2384045770C86803240 @default.
- W2384045770 hasLocation W23840457701 @default.
- W2384045770 hasOpenAccess W2384045770 @default.
- W2384045770 hasPrimaryLocation W23840457701 @default.
- W2384045770 hasRelatedWork W1543594511 @default.
- W2384045770 hasRelatedWork W1963859510 @default.
- W2384045770 hasRelatedWork W2023789867 @default.
- W2384045770 hasRelatedWork W2055450660 @default.
- W2384045770 hasRelatedWork W2060594667 @default.
- W2384045770 hasRelatedWork W2274862898 @default.
- W2384045770 hasRelatedWork W2314997333 @default.
- W2384045770 hasRelatedWork W2349675614 @default.
- W2384045770 hasRelatedWork W2359708683 @default.
- W2384045770 hasRelatedWork W2360165777 @default.
- W2384045770 hasRelatedWork W2364946262 @default.
- W2384045770 hasRelatedWork W2370786107 @default.
- W2384045770 hasRelatedWork W2409015308 @default.
- W2384045770 hasRelatedWork W2419152522 @default.
- W2384045770 hasRelatedWork W2725807938 @default.
- W2384045770 hasRelatedWork W2788726634 @default.
- W2384045770 hasRelatedWork W2797612554 @default.
- W2384045770 hasRelatedWork W3098558533 @default.
- W2384045770 hasRelatedWork W3118199282 @default.
- W2384045770 hasRelatedWork W3210380098 @default.
- W2384045770 isParatext "false" @default.
- W2384045770 isRetracted "false" @default.
- W2384045770 magId "2384045770" @default.
- W2384045770 workType "article" @default.