Matches in SemOpenAlex for { <https://semopenalex.org/work/W2384049972> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2384049972 abstract "Objective To prepare poly(lactic-co-glycolic acid)(PLGA)microspheres containing paclitaxel(PTX),and to evaluate their physicochemical properties and in vitro inhibitory effect on tumor cells.Methods PLGA microspheres containing PTX were prepared by the double emulsion evaporation method.The morphology and grain diameters of microspheres were observed by a scanning electron microscope(SEM)and an optical microscope.HPLC was used to detect the drug loading amount and encapsulation efficiency.Cultured cells of the human ovarian carcinoma cell line SKOV3 were treated with RPMI1640 as blank controls,normal saline(NS),PLGA,PTX and PTX-PLGA microspheres.The proliferation of SKOV3 cells was determined by MTT assay and the morphological change was observed under an inverted microscope.Results The microspheres with a mean particle size of(2.00±0.19)μm were uniform and smooth.Drug loading amount and encapsulation efficiency were 5.68% and 81.10%,respectively.Proliferation of SKOV3 cells was significantly inhibited by PTX-PLGA microspheres at 1×105mol/L in 72 h(P0.05).Conclusion PTX-PLGA microspheres prepared by this method are stable and have sustained release effect on inhibiting proliferation of SKOV3 cells in vitro." @default.
- W2384049972 created "2016-06-24" @default.
- W2384049972 creator A5034577233 @default.
- W2384049972 date "2011-01-01" @default.
- W2384049972 modified "2023-09-23" @default.
- W2384049972 title "Preparation of paclitaxel-loaded PLGA microspheres and their in vitro inhibitory effect on tumor cells" @default.
- W2384049972 hasPublicationYear "2011" @default.
- W2384049972 type Work @default.
- W2384049972 sameAs 2384049972 @default.
- W2384049972 citedByCount "0" @default.
- W2384049972 crossrefType "journal-article" @default.
- W2384049972 hasAuthorship W2384049972A5034577233 @default.
- W2384049972 hasConcept C127413603 @default.
- W2384049972 hasConcept C13965031 @default.
- W2384049972 hasConcept C141071460 @default.
- W2384049972 hasConcept C159985019 @default.
- W2384049972 hasConcept C185592680 @default.
- W2384049972 hasConcept C189942447 @default.
- W2384049972 hasConcept C192562407 @default.
- W2384049972 hasConcept C202751555 @default.
- W2384049972 hasConcept C26771246 @default.
- W2384049972 hasConcept C2776694085 @default.
- W2384049972 hasConcept C2777292972 @default.
- W2384049972 hasConcept C2777521759 @default.
- W2384049972 hasConcept C2780165375 @default.
- W2384049972 hasConcept C2780783641 @default.
- W2384049972 hasConcept C42360764 @default.
- W2384049972 hasConcept C43617362 @default.
- W2384049972 hasConcept C55493867 @default.
- W2384049972 hasConcept C71924100 @default.
- W2384049972 hasConceptScore W2384049972C127413603 @default.
- W2384049972 hasConceptScore W2384049972C13965031 @default.
- W2384049972 hasConceptScore W2384049972C141071460 @default.
- W2384049972 hasConceptScore W2384049972C159985019 @default.
- W2384049972 hasConceptScore W2384049972C185592680 @default.
- W2384049972 hasConceptScore W2384049972C189942447 @default.
- W2384049972 hasConceptScore W2384049972C192562407 @default.
- W2384049972 hasConceptScore W2384049972C202751555 @default.
- W2384049972 hasConceptScore W2384049972C26771246 @default.
- W2384049972 hasConceptScore W2384049972C2776694085 @default.
- W2384049972 hasConceptScore W2384049972C2777292972 @default.
- W2384049972 hasConceptScore W2384049972C2777521759 @default.
- W2384049972 hasConceptScore W2384049972C2780165375 @default.
- W2384049972 hasConceptScore W2384049972C2780783641 @default.
- W2384049972 hasConceptScore W2384049972C42360764 @default.
- W2384049972 hasConceptScore W2384049972C43617362 @default.
- W2384049972 hasConceptScore W2384049972C55493867 @default.
- W2384049972 hasConceptScore W2384049972C71924100 @default.
- W2384049972 hasLocation W23840499721 @default.
- W2384049972 hasOpenAccess W2384049972 @default.
- W2384049972 hasPrimaryLocation W23840499721 @default.
- W2384049972 hasRelatedWork W2010672303 @default.
- W2384049972 hasRelatedWork W2010796656 @default.
- W2384049972 hasRelatedWork W2042359510 @default.
- W2384049972 hasRelatedWork W2045990351 @default.
- W2384049972 hasRelatedWork W2061562937 @default.
- W2384049972 hasRelatedWork W2072122302 @default.
- W2384049972 hasRelatedWork W2083305417 @default.
- W2384049972 hasRelatedWork W2183366736 @default.
- W2384049972 hasRelatedWork W2320790508 @default.
- W2384049972 hasRelatedWork W2354040196 @default.
- W2384049972 hasRelatedWork W2381063923 @default.
- W2384049972 hasRelatedWork W2390875980 @default.
- W2384049972 hasRelatedWork W2527469432 @default.
- W2384049972 hasRelatedWork W2944371068 @default.
- W2384049972 hasRelatedWork W2999850420 @default.
- W2384049972 hasRelatedWork W3020660930 @default.
- W2384049972 hasRelatedWork W3035649613 @default.
- W2384049972 hasRelatedWork W3043829104 @default.
- W2384049972 hasRelatedWork W3207893057 @default.
- W2384049972 hasRelatedWork W2291066604 @default.
- W2384049972 isParatext "false" @default.
- W2384049972 isRetracted "false" @default.
- W2384049972 magId "2384049972" @default.
- W2384049972 workType "article" @default.