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- W2384053090 abstract "To investigate the molecular mechanisms of the anti-apoptosis effects of hematopoietic growth factors GM-CSF/IL-3 fusion protein, GM-CSF and IL-3 in Tf-1 cells induced by γ-irradiation. Caspase-3 activity was detected using fluorescence chromatometry. RT-PCR semiquantitative analysis was used to identify the expression changes of Bcl-2 and Caspase-3 mRNA, and an immunohistochemical technique was used to examine the protein expression in irradiated Tf-1 cells. The Caspase-3 activity in irradiated Tf-1 cells was markedly reduced to 15.71 %-43.65% in GM-CSF/IL-3 fusion protein, GM-CSF, IL-3, and the combination of GM-CSF and IL-3-treated groups compared to those in the control groups without any growth factor. Bcl-2 mRNA and its protein expression were significantly increased by the above cytokines after incubation with the cells for 48 h after irradiation, while the enhancement of the Bcl-2 mRNA level by GM-CSF / IL-3 fusion protein (10 μg / L) began from 24 h. After 48 h of incubation after irradiation, the expression of Caspase-3 mRNA was dramatically augmented by GM-CSF / IL-3 fusion protein at 10 μg / L, 100 μg / L and IL-3 10 μg / L, as was the corresponding Caspase-3 protein expression by the addition of each cytokine. The cytokines exerted the anti-apoptosis effects in irradiated Tf-1 cells through the up-regulation of Bcl-2 and Caspase-3 expression, and the inhibition of Caspase-3 activity." @default.
- W2384053090 created "2016-06-24" @default.
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- W2384053090 date "2005-01-01" @default.
- W2384053090 modified "2023-09-25" @default.
- W2384053090 title "Molecular mechanisms of anti-apoptosis effects of GM-CSF/IL-3 fusion protein, GM-CSF and IL-3 in Tf-1 cells irradiated by y-rays" @default.
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