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- W2384072034 abstract "Objective:To investigate the methylation status of RASSF1A gene in human osteosarcomas.Methods:Methyla-tion-specific PCR(MSP) was used to detect the status of promoter hypermethylation of RASSF1A gene in 44 osteosarcoma and corre-sponding non-tumor bone tissues and the clinicopathological significance in human osteosarcoma was analyzed.Results:The methylation ratio of RASSF1A gene in osteosarcoma tissues(61.4%) was obviously higher than that in non-tumor bone tissues(20.5%,P0.05).The abberant methylation of RASSF1A gene induced the decreased expression of RASSF1A mRNA and protein in osteosarcoma or non-tu-mor bone tissues.Additionally,the methylation of RASSF1A gene was significantly associated with tumor differentiation and metastasis(P=0.022 and 0.016,respectively),but it had not associated with age,sex,tumor location and size of osteosarcoma patients(P=0.6944,0.977,0.786 and 0.831,respectively).Conclusion:The methylation of RASSF1A gene may contribute to the decreased RASSF1A gene expression,and detection of RASSF1A promoter methylation might be an important molecular marker for the earlier auxiliary diagnosis of osteosarcoma." @default.
- W2384072034 created "2016-06-24" @default.
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- W2384072034 date "2011-01-01" @default.
- W2384072034 modified "2023-09-24" @default.
- W2384072034 title "Analysis of Methylation Status of RASSF1A Gene in Human Osteosarcoma" @default.
- W2384072034 hasPublicationYear "2011" @default.
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