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- W2384075995 abstract "Objective To study the relation between the Bcl-2 protein family and the apoptosis of HepG2 induced by Ad.mda-7.Methods The MDA-7/IL-24 gene was transfected into HepG2 and L02 cells with a replication-incompetent adenovirus vector.MTT assay and Hoechst staining were used to observe the growth inhibitory and killing effects of MDA-7/IL-24 on HepG2 and L02.After double staining with Annexin-V and PI,the apoptosis was detected by using flow cytometry.The changes of Bcl-2 protein family were observed by Western blot.Results MTT revealed that Ad.mda-7 could suppress the grwoth of HepG2 cells,but could not inhibit the proliferation of L02 cells.Hoechst staining and flow cytometry indicated Ad.mda-7 could obviously induce the apoptosis of HepG2,but had no cytotoxic effects on L02 cells.Western blot showed the expression of protein Bcl-2 and Bcl-xl was significantly decreased in HepG2 cells after infected with Ad.mda-7,but not in L02 cells,while the expression of Bax protein was increased in both HepG2 and L02.Conclusion The apoptosis of HepG2 induced by Ad.mda-7 had something to do with the change in the ratio of pro-(Bax) to antiapoptoptic (Bcl-2 and Bcl-xl) proteins." @default.
- W2384075995 created "2016-06-24" @default.
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- W2384075995 date "2008-01-01" @default.
- W2384075995 modified "2023-09-25" @default.
- W2384075995 title "The change of Bcl-2 protein family by the Ad.mda-7-induced apoptosis in HepG2 cells" @default.
- W2384075995 hasPublicationYear "2008" @default.
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