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- W2384094598 abstract "Aim To observe the effects and mechanism of polygalasaponin F(PS-F) on PC12 cellular apoptosis induced by 1-methyl-4-phenylpyridinium ion(MPP+).Methods MTT assay was used to measure the viability of the PC12 cells and flow cytometry was used to analyze the apoptotic rate of PC12 cells.The expression of active Caspase-3 in PC12 cells was detected by Western blot.In addition,the mitochondrial membrane potential was determined by JC-1 staining inverted microscope.Results When exposed to 500 μmol·L-1 MPP+ for 48 h,the viability and the mitochondrial membrane potential of PC12 cells decreased significantly,and the apoptosis rate and the expression of active Caspase-3 were increased significantly.Treatment with PS-F,the cell viability(P0.01) and the MMP were significantly increased,the apoptosis rate and the expression of active Caspase-3(P0.01) were significantly decreased compared with MPP+ group.Conclusion PS-F protects PC12 cells against apoptosis induced by MPP+ and the mechanism may be related to ameliorate the mitochondrial dysfunction and decrease the expression of active Caspase-3." @default.
- W2384094598 created "2016-06-24" @default.
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- W2384094598 date "2012-01-01" @default.
- W2384094598 modified "2023-09-23" @default.
- W2384094598 title "The protective effect of polygalasaponin Fagainst MPP~+ induced PC12 cellular apoptosis" @default.
- W2384094598 hasPublicationYear "2012" @default.
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