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- W2384098072 abstract "Plackett-Burman design combined with the path of steepest ascent method and response surface methodology was used for the optimization of the culture medium for daptomycin fermentation.Experimental design and data analysis were obtained by Design Expert 7.0.The results indicated that the major factors on daptomycin fermentation were dextrin,yeast extract and casamino acid.The optimized composition(g·L-1) of the culture medium was dextrin 10.6,yeast extract 1.6,casamino acid 1.3,K2SO4 8,L-aspartic acid 1.5;pH 6.5.Under the optimized condition,the yield of daptomycin was 37.16 mg/L.After optimization of the addition of its precursor,the yield of daptomycin could reach to 46.54 mg/L." @default.
- W2384098072 created "2016-06-24" @default.
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- W2384098072 date "2010-01-01" @default.
- W2384098072 modified "2023-09-28" @default.
- W2384098072 title "Optimization of Medium for Daptomycin Fermentation by Response Surface Methodology" @default.
- W2384098072 hasPublicationYear "2010" @default.
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