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- W2384102704 abstract "Objective To prepare the total ginkgo flavonoid(TGF) self-microemulsifying oral fast dissolving films(SMEOFDF) and evaluate its in vitro properties.Methods The formulation of TGF self-microemulsifying drug delivery system(SMEDDS) was optimized based on the solubility method and the pseudo-ternary phase diagram,and then the influence of formulation on disintegration time and film forming property were observed by single factor test.Microemulsified performance,disintegration time,content uniformity,and release profiles in vitro were investigated.The surface feature of TGF SMEOFDF was detected by scanning electron microscope and the crystal form of drug was characterized by differential scanning calorimetry.Results The average particle size was(48.1 ± 5.45) nm with non-difference from SMEDDS.The average time to disintegrating was(9.94 ± 0.26) s and the releasing drug at 5 min of TGF SMEOFDF was(70.98 ± 0.31)% in vitro.Conclusion SMEOFDF which has both advantages of SMEDDS and fast dissolving oral films is a new dosage form with profound application prospect." @default.
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- W2384102704 date "2011-01-01" @default.
- W2384102704 modified "2023-09-23" @default.
- W2384102704 title "Preparation and characterization of self-microemulsifying oral fast dissolving films of total ginkgo flavonoid." @default.
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