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- W2384104123 abstract "Objective To explore the expression and significance of T lymphocyte subpopulation in peripheral blood of Uygur and Han Chinese patients with hepatitis C. Methods Total of 247 cases with hepatitis C, serum levels of antibody of HCV were detected by enzyme-linked immunosorbent assay, HCV RNA were detected by ?uorescence quantitative polymerase chain reaction, and T lymphocyte subpopulation were analysed by flow cytometry. Results The rates of CD4+% and CD4+/CD8+ were markedly lower in Uygur patients [(31.23 ± 17.16) and(0.65 ± 0.37)]% than those of the Han Chinese patients [(41.25 ± 16.13) % and(0.92 ± 0.38)]%, and the rates of CD8+% were markedly higher in Uygur patients(60.25 ± 26.36)% than(52.91±22.59)% of Han Chinese patients, and there were significant differences(t = 4.65, 5.52, 2.30; P = 0.00, 0.00, 0.02). Conclusions Our study suggest there could be different in immune function of hepatitis C between Uygur and Han Chinese patients, the positive rate of HCV RNA were markedly higher in Uygur patients, and the lower immune function of CD4+ T lymphocyte maybe one of the major reasons for continuous HCV infection and immunologic tolerance, the changes of lymphocyte subpopulation in patients with continuous HCV infection contribute to the progression of chronic hepatitis C and clinical should pay attention to the characteristics." @default.
- W2384104123 created "2016-06-24" @default.
- W2384104123 creator A5072495806 @default.
- W2384104123 date "2013-01-01" @default.
- W2384104123 modified "2023-09-24" @default.
- W2384104123 title "Analysis on T lymphocyte subpopulation between Uygurs and Han Chinese patients with hepatitis C" @default.
- W2384104123 hasPublicationYear "2013" @default.
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