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- W2384108538 abstract "Objective To explore the change of Cx43/ Cx45 heteromeric gap junction in the model of subarachnoid hemorrhage(SAH)of rabbits,and to provide the basis to investigate whether gap junction play an important role in the mechanism of cerebral vasospasm(CVS).Methods 36 New Zealand rabbits were divided into 3 groups:control group(n=12),SAH-7d group(n=12)and SAH-7d+CBX group.The model of CVS following SAH was established.Digital subtraction angiography was performed to detect the change of the basilar arteries diameter before and after SAH.The interaction of Cx43 and Cx45 protein in basilar arteries tissue of different groups following experimental SAH was examined by using co-immunoprecipitation analysis.Results The model of SAH in rabbits was successfully established.All 36 rabbits were analyzed.Cerebral angiograms of the basilar arteries of SAH-7d group showed much more narrowing than control group and SAH-7d +CBX group(P0.01).Co-Immunoprecipitation showed that the interaction of Cx43 and Cx45 protein were increased significantly compared with that of control and SAH-7d +CBX group(P0.01).Conclusions The above results demonstrate that the interaction of Cx43 and Cx45 protein was increased after the SAH,in other words,Cx43 and Cx45 form heteromeric gap junctions were also increased after the SAH,however,the gap junction blocker CBX inhibited this tendency.which suggest that increased Cx43 /Cx45 heteromeric gap junctions might be connected with the development of CVS.In summary,our data demonstrate that Cx43 /Cx45 heteromeric gap junctions may play an important role in the pathogenesis of CVS after SAH." @default.
- W2384108538 created "2016-06-24" @default.
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- W2384108538 date "2012-01-01" @default.
- W2384108538 modified "2023-09-27" @default.
- W2384108538 title "Cx43 and Cx45 formed heteromeric gap junction may play an important role in cerebral vasospasm due to experimental subarachnoid hemorrhage" @default.
- W2384108538 hasPublicationYear "2012" @default.
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