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- W2384114597 abstract "Objective To investigate serotype/serogroup distribution of S. pneumoniae in children with community-acquired pneumonia in Shenzhen,understand possible vaccine coverage of the serotypes and the bacterial resistance to 8 antibiotics. Methods S. pneumoniae strains were isolated from the sputum,cerebrospinal fluid,blood and pleural effusion of children with community-acquired pneumonia in Shenzhen during February 2006 and February 2007. The isolates were serotyped by capsular swelling technique. Susceptibility to 8 antibiotics was determined by E-test. Results Ninety strains of S. pneumoniae were isolated from 1 011 specimens. The prevalence was 8.9%. Of these isolates,89 were from sputum,1 from pleural effusion. Serotype 19F was the most frequently isolated type (62.2%,56/90),followed by 23F (15.6%,14/90),6B (10.0%,9/90),4 (6.7%,6/90). These 4 serotypes accounted for 94.4% of all isolates. About 94.4% of these isolates were covered by the 7-valent pneumococcal conjugate vaccine (PCV7). The additional serotypes contained in 9,10 and 11-valent pneumococcal conjugate vaccines were not identified. The coverage of 13-valent pneumococcal conjugate vaccine was 97.8%,showed no significant difference from that of PCV7 (χ 2=1.34,P0.05). Of the serotypes in PCV7,14.1% were resistant to penicillin. About 13.3% of all S. pneumoniae isolates were resistant to penicillin. No resistant strain was found to vancomycin,levofloxacin or imipenem. About 98.9%,64.4% and 4.4% of the isolates were resistant to erythromycin,cefuroxime and ceftriaxone respectively. Conclusions The 19F,23F,6B and 4 serotypes are the most frequently isolated pneumococcal strains in children with community-acquired pneumonia in Shenzhen area. PCV7 can cover 94.4% of these S. pneumoniae strains. These S. pneumoniae strains are highly sensitive to vancomycin,levofloxacin,amoxicillin and imipenem,but relatively resistant to penicillin,erythromycin and cefuroxime." @default.
- W2384114597 created "2016-06-24" @default.
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- W2384114597 date "2010-01-01" @default.
- W2384114597 modified "2023-09-26" @default.
- W2384114597 title "Serotype/serogroup distribution and antimicrobial resistance of Streptococcus pneumoniae in children with community-acquired pneumonia in Shenzhen area" @default.
- W2384114597 hasPublicationYear "2010" @default.
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