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- W2384122010 abstract "Objective To discuss the STAT3's role for development of cervical carcinoma and the effect of quercetin for STAT3 expression on cancer cells.Methods The expressions of STAT3 mRNA with different concentrations of quercetin were detected by RT-PCR and STAT3 and phosphorylation of STAT3 (P-STAT3)in human cervical carcinoma HeLa cells were observed by immunofluorescence.Results When the quercetin concentration varied 6.25 μmol/L from 50 μmol/L,STAT3 mRNA was decreased gradually in HeLa cells,and expression of STAT3 mRNA in different concentrations was significantly lower compared with the DMSO control group excluding the group of 6.25 μmol/L in the same time,the differences were statistically significant (P0.05), and for 24 hours,STAT3 mRNA expression was negatively correlated with the dose levels,r1=-0.861,P=0.000;different concentrations (6.25,12.5,25,50 μmol/L)compare with each other in the each time,the differences were statistically significant(P0.05).As time changes,in the same concentration group,STAT3 mRNA expression was lower,in the group of 6.25 μmol/L,STAT3 mRNA expression was a time-dependent manner,r2=-0.539,P=0.000.STAT3 protein and its phosphorylation levels were significantly reduced by immune fluorescent technique.Conclusions Quercetin can inhibit the growth of HeLa cells;quercetin may inhibit the expression of STAT3 in cells,and induce the apoptosis of cervical cancer cells by inhibiting the JAK/STAT signaling pathway." @default.
- W2384122010 created "2016-06-24" @default.
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- W2384122010 date "2011-01-01" @default.
- W2384122010 modified "2023-09-23" @default.
- W2384122010 title "Effect of quercetin on the expression of STAT3 and its signal pathway in HeLa cells" @default.
- W2384122010 hasPublicationYear "2011" @default.
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