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- W2384124885 abstract "Objective To observe the effect of alcoholic extract from Radix puerariae on soluble vascular cell adhesion molecule 1(sVCAM-1)and TNF-αin serum of rats with large vessel injury of obese T2MD,and approach the mechanism of preventing large vessel injury of obese T2MD.Method 30 Wistar rats were fed by fat milk of 1ml/100g.After three weeks adipositas Wistar rats with high levels of TC,TG and LDL,and low level of insulin sensitivity index(ISI) were selected from 30 Wistar rats.T2DM model of these rats were established by vena caudalis injection of STZ,30 mg/kg.Rats model with large vessel injury of obese T2MD were confirmed by observation of pathological change of aorta thoracica arcual.These model rats were randomly divided into alcoholic extract from Radix puerariae group(receive alcoholic extract from Radix puerariae,0.9 g/kg),Metformin group(receive Metformin,0.09g/kg) and model group(receive tap-water).8 normal rats were as control group.After four weeks,these rats were executed and contents of sVCAM-1 and TNF-α in serum were measured.Results sVCAM-1 and TNF-α in serum in model group were higher than those in control group.sVCAM-1 and TNF-α in serum in alcoholic extract from Radix puerariae group and Metformin group were obviously decreased in comparison with those in control group(P0.05).Conclusion Alcoholic extract from Radix puerariae can control development of blood vessel complication of T2DM by decreasing of sVCAM-1 and TNF-α in serum of rat with blood vessel complication of T2DM." @default.
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- W2384124885 date "2008-01-01" @default.
- W2384124885 modified "2023-09-23" @default.
- W2384124885 title "Study of alcoholic extract from Radix puerariae on sVCAM-1 and TNF-α in serum of rats with large vessel injury of obese T2MD" @default.
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