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- W2384125588 abstract "Objective To assess the effects of ursodeoxycholic acid (UDCA) in preventing immunodamaged hepatic fibrosis induced by pig serum in rats,and to explore its mechanisms of anti-fibrosis.Methods Thirty-six Sprague Dawley rats were randomly divided into three equal groups. Hepatic fibrotic models were established by injection of pig serum into the peritoneal cavity twice/week for 8 weeks in two groups. One of them was treated with UDCA 15mg/(kg·d) for 8 weeks(UDCA group), the other was regarded as model group. The remaining group was without any treatment(control group). All rats were sacrificed 8 weeks later. Liver fibrosis was assessed directly by hepatic morphometric analysis, the levels of hyaluronic acid (HA), hydroxyproline(Hyp) were evaluated,and the expression of α-smooth muscle actin (α-SMA),transforming growth factor-beta 1(TGF-β_1),nuclear factor-NF κ B (NF κ B p65) in liver tissue were detected by immunohistochemical techniques. The data from UDCA group was compared with that from model group and control group respectively.Results The area of collagen of liver tissue in model group was much higher than that in control group(11.1±2.09 vs. 0.73±0.15, P0.05), and so did the serum level of HA, Hyp and the expression of α-SMA, TGF-β_1 and NF κ Bp65 (P0.05). Compared with model group,the area of collagen in UDCA group was not markedly decreased (9.49+1.31 vs. 11.1+2.09, P0.05).The same results were obtained from other indexes(P0.05).Conclusions UDCA with ordinary dosage may not significantly delay the progression of pig serum-induced liver fibrosis in rats." @default.
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- W2384125588 date "2004-01-01" @default.
- W2384125588 modified "2023-09-23" @default.
- W2384125588 title "Effects of ursodeoxycholic acid (UDCA) on immunodamaged hepatic fibrosis in rats" @default.
- W2384125588 hasPublicationYear "2004" @default.
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