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- W2384128435 abstract "Objective:To compare the genistein-induced vasorelaxant effect and its correlated mechanisms using vascular tension change as the index.Methods:Canine basilar arterial rings were prepared and then mounted in the organ bath,after an equilibration period,the changes treated with the drugs were observed.Results:GST caused the dose-response contractile curve of KCl in K-H shift rightward,NA and CaCl2 in Ca2+-free K-H solution in biphasic response and their sensitivies and the values of maximum contractions were decreased.(2)After incubation with inhibitor of nitric oxide synthase Nω-L-nitro-arginine(L-NNA),methylene blue(MB),indomethacin(INDO),glibenclamide(GLM) and endothelium removal,genistein induced-relaxation had no change(P0.05).Conclusion:(1)Genistein induces the vasorelaxant response mainly via inhibition of voltage-dependent calcium channel and Ca2+ release from intracellular stores induced by NA in Ca2+-free K-H solution.(2)The vasorelaxant effect of genistein is probably endothelium-independent and not related to NO and prostaglandins and as well as KATP channel in isolated basilar arterial rings." @default.
- W2384128435 created "2016-06-24" @default.
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- W2384128435 date "2009-01-01" @default.
- W2384128435 modified "2023-09-24" @default.
- W2384128435 title "Relaxant effect of genistein on canine basilar arteries in vitro and its mechanism" @default.
- W2384128435 hasPublicationYear "2009" @default.
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