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- W2384149723 abstract "Objective To observe the effects of intravenous captopril on the cardiovascular responses to intraperitoneal insufflation of carbon dioxide during laparoscopic surgery. Methods Fifty-two ASA Ⅰ- Ⅱ patients (aged 26-60 years) scheduled for elective laparoscopic cholecystectomy were randomly divided into two groups: control group (n=26) and captopril group (n=26). The patients received normal saline in control group and captopril 0.4mg/kg in captopril group 10 min before intraperitoneal insufflation of carbon dioxide. HR、SP、DP and MAP of all patients were continuously monitored;Blood samples were collected 15 min before insufflation of carbon dioxide (T0) ; 1 min (T1) 、5min (T2) and 10 min (T3) after goal intra-abdominal pressure obtained. plasma renin activity (PRA) and angiotensin Ⅱ(AⅡ) were assaied with radioimmunassay. Results During intraperitoneal insufflation of carbon dioxide ,in control group, HR、SP、DP、MAP and RPP of patients were significantly increased as compared with the T0 (P0.01),while in captopril group, these parameters either remained unchanged or increased only slightly.There were significant difference in cardiovascular responses and plasma level of PRA and AⅡ between the two groups (P0.01) after the pneumoperitoneum was estabished. Conclusion Captopril may be effectively attenuate the cardiovascular responses to intraperitoneal insufflation of carbon dioxide during laparoscopic surgery." @default.
- W2384149723 created "2016-06-24" @default.
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- W2384149723 date "2009-01-01" @default.
- W2384149723 modified "2023-09-25" @default.
- W2384149723 title "Effects of Intravenous Captopril on Cardiovascular Responses during Laparoscopic Surgery" @default.
- W2384149723 hasPublicationYear "2009" @default.
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