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- W2384151567 abstract "Objective To investigate the effects of carbachol(a cholinergic agent) on gastric emptying and gastric blood flow with oral resuscitation of glucose electrolyte solution(GES) in rats with 40% blood volume loss.MethodsSD rats were randomly divided into three groups: oral GES without hemorrhage(GES group),hemorrhage resuscitated with oral GES(H+GES),and hemorrhage resuscitated with oral carbachol plus GES(GES/CAR).About 40% of total blood volume was drawn from carotid artery to produce a model of hemorrhagic shock in all groups.The volume of GES was two times more than that of blood loss,and given intragastricly at 0.5hours and 1 hour after bleeding respectively.Carbachol(60μg·kg.BW-1)was given in the first intragastric administration.The gastric emptying rate was detected with method of phenol red and gastric blood flow were determined by laser Doppler at 2 hours and 4 hours after hemorrhage.ResultsThe gastric emptying decreased by 51.4% and 30.2%,and gastric blood flow decreased by 50.0% and 35.2% at 2 hours and 4 hours in H+GES group respectively compared with those in GES group(P0.01 and P0.05).The gastric emptying and gastric blood flow in GES/CAR group were dramatically higher compared with those in H+GES group(P0.05) and were not statistically different from that in GES group at 4 hours after bleeding(P0.05).ConclusionThe results indicate that carbachol has significant effect on improving gastric emptying and gastric blood flow in the oral fluid resuscitation of hemorrhagic shock." @default.
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- W2384151567 date "2009-01-01" @default.
- W2384151567 modified "2023-09-23" @default.
- W2384151567 title "Effects of carbachol on gastric emptying and gastric blood flow in the oral fluid resuscitation of 40% blood volume loss in rats" @default.
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