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- W2384151937 abstract "Objective To observe the effects of different doses of atorvastatin on neurologic impairment,blood lipid,carotid intimamedia thickness in acute cerebral infarction patients.Methods Totally 80 acute cerebral infarction patients with normal cholesterol were randomly divided into atorvastatin group(n =40) and control group(n =40).Atorvastatin group received 40 mg atorvastatin per day and control group received 20 mg atorvastatin per day based on normal treatment for 6 months.Serum concentration of cholesterol was measured after treatment for 3 and 6 months,intima-media thickness and plaques was measured at 6 months,the scores of neural function defect and modified Barthel index were measured 1 month after admission and at 3 and 6 months.Results The serum concentrations of TC,LDL-C,TG after 3-month treatment and the scores of neural function defect decreased significantly in atorvastatin group after 6-months treatment.Carotid intima-media thickness(IMT) decreased significantly in atorvastatin group after 6-month treatment.There were statistic differences between two groups(P 0.05).The serum concentration of HDL-C,the scores of Barthel index increased significantly,with statistic differences between the two groups(P 0.05).Conclusions High dose atorvastatin has protective effects on patients with acute cerebral infarction.It has positive effecls on the recovery of nervous system after cerebral infarction,increases stabilization of atherosclerotic plaques.Beneficial effects on normalising blood lipid level and anti-atherosclerotic function is also observed." @default.
- W2384151937 created "2016-06-24" @default.
- W2384151937 creator A5001876116 @default.
- W2384151937 date "2014-01-01" @default.
- W2384151937 modified "2023-09-23" @default.
- W2384151937 title "Effects of different doses of atorvastatin on efficacy,blood lipid,and carotid intima in patients with cerebral infarction" @default.
- W2384151937 hasPublicationYear "2014" @default.
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