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- W2384155178 abstract "Objective To study the effects of bisphenol A(BPA)on spermatogenesis and the development of reproductive organs in weanling rats.Methods 40 Wistar male rats(4 weeks old)were equally divided into 4 groups,including vehicle control(maize oil)and 3 BPA treatment groups(50,100 and 200 mg/kg,respectively).BPA(2 ml/kg)was used subcutaneously one time a day,four days a week(Monday,Tuesday,Thursday,Friday)for 6 weeks.Testis,epididymis,prostate,seminal vesicle were weighted,organ coefficients were calculated and histopathological changes were examined.The contents of T and E2 in serum were detected by ELISA.The count,motility and malformation of sperm in the rats were also tested.Results In the exposure groups,with the doses of BPA increased,the weights and the organ coefficients of prostate and seminal vesicle were decreased,which was significantly different with those of the control group(P0.05 or P0.01).The count and motility of sperm and the level of T in 200 mg/kg group were lower than those of the control group(P0.01 or P0.05).Smooth muscle absence,basilar membrane cell arrangement disorder of prostate and reduced liquid volume in spermatophore in 200 mg/kg group were observed.Conclusion BPA could damage the development of reproductive organs and the sperm quality in weanling rats." @default.
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- W2384155178 date "2008-01-01" @default.
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- W2384155178 title "Effects of bisphenol A on the development of reproductive organs in weanling rats" @default.
- W2384155178 hasPublicationYear "2008" @default.
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