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- W2384161791 abstract "[Objective] To assess the neurotoxicity of calcium carbonate nanoparticles(nano-CaCO3) by observing the changes in spontaneous activity and learning and memory of rats with subchronic exposure to nano-CaCO3. [Methods] Fifty healthy male SD rats were randomly divided into a solvent control group(saline), a micro-CaCO3 group(200 mg/kg), and three nanoCaCO3 groups(12.5, 50, and 200 mg/kg), 10 rats in each group. The test substances were administered to rats by nasal instillation five times per week for twelve weeks. Open field test and Morris water maze were performed to test the spontaneous activity and the learning and memory ability of rats. [Results] Depression was found in the rats exposed to micro-CaCO3 or nano-CaCO3. There was no significant difference in body weight and brain-to-body weight ratio among all groups(P 0.05). The results of open field test showed no significant differences in time spent in center, total distance traveled, and times of vertical activity among all groups(Fvalues were 0.799, 0.623, and 0.251, all P 0.05). The results of Morris water maze showed no significant differences in average escape latency, average path length, times of passing through platform, and residence time in platform quadrant among all groups(Fvalues were 0.475, 0.345, 0.046, and 0.252, all P 0.05). [Conclusion] No obvious damage to spontaneous activity and learning and memory of rats exposed to nano-CaCO3 is found in this experiment setting." @default.
- W2384161791 created "2016-06-24" @default.
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- W2384161791 date "2014-01-01" @default.
- W2384161791 modified "2023-09-23" @default.
- W2384161791 title "Neurobehavior of Rats Following Subchronic Exposure to Calcium Carbonate Nanoparticles" @default.
- W2384161791 hasPublicationYear "2014" @default.
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