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- W2384162563 abstract "Objective To compare the clinical efficacy and safety between sildenafil and phentolamine in the treatment of essential hypertension. Methods Erectile dysfunction patients(223 cases) who came to Nanjing Maternity and Child Health Care Center from June 2011 to June 2014 were randomly divided into control(n = 108) and treatment(n = 115) groups. The patients in the control group were po administered with Mesylate Phentolamine Tablets 0.5 — 1 h before sexual intercourse, 1 tablet/time. The patients in the treatment group were po administered with Citrate Sildenafil Tablets 0.5 — 1 h before sexual intercourse. For the first time, the recommended dosage was 50 mg, then the adjusting dosage ranged from 25 mg to 100 mg according to the individual effect. The patients in two groups took the drugs at least one time daily but not more than 4 times a week, and the patients in the two groups were treated for 8 weeks. After the treatment, the efficacy was evaluated, while IIEF-5 score, EQS score, average working time, and duration of sexual intercourse in two groups were compared. Results The efficacies in the treatment and control groups were 86.9% and 63.9%, respectively, with differences between the two groups(P 0.05). After treatment, IIEF-5 score and EQS score in two groups were significantly increased, and the difference was statistically significant in the same group(P 0.05). After treatment, the two scores in the treatment group were significantly higher than those of the control group, with significant difference between two groups(P 0.05). The times of average working and duration of sexual intercourse in treatment group were longer than those in the control group, with significant difference between two groups(P 0.05). Conclusion Sildenafil has the good clinical effect in treatment of essential hypertension, and the curative effect is better than that of phentolamine, which can be used widely in clinical." @default.
- W2384162563 created "2016-06-24" @default.
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- W2384162563 date "2014-01-01" @default.
- W2384162563 modified "2023-09-27" @default.
- W2384162563 title "Comparison on clinical efficacy between sildenafil and phentolamine in treatment of essential hypertension" @default.
- W2384162563 hasPublicationYear "2014" @default.
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