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- W2384167129 abstract "Objective To investigate the role of connective tissue growth factor(CTGF)and collagen typeⅠ(COL-Ⅰ),Ⅲ(COL-Ⅲ)in the pathogenesis of the scleroderma skin lesion.Methods The Expression of CTGF and collagen typeⅠand Ⅲ in the skin lesions from 72 patients with SD and skin from 18 normal controls were detected by immunohistochemical method.Results ①There was a significantly stronger expression of CTGF of the SD group in the lesional skin than that in normal controls(P0.001,respectively),and significant difference was found between the localized SD and SSc patients.②The expression of collagen typeⅠin the skin lesions of SD group was higher compared with that of the controls(P0.001),and significant difference was not found between the localized SD and SSc patients.There was no significant difference of collagen TypeⅢamong the localized SD,SSc patients and normal controls(P0.05 respectively);and the direct correlation between the Expression of CTGF and collagen typeⅠin the SD group of sclerotic skin were found(P0.05).Conclusion CTGF and collagen typeⅠwere produce intensely in the skin lesions of the SD group,there are direct correlation between the expression of CTGF and collagen typeⅠin the skin lesions of scleroderma patients,this implies that they may be involved in the pathogenesis of scleroderma." @default.
- W2384167129 created "2016-06-24" @default.
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- W2384167129 date "2008-01-01" @default.
- W2384167129 modified "2023-09-28" @default.
- W2384167129 title "The Expression of Connective Tissue Growth Factor and Collagen TypeI,III in the Scleroderma Skin Lesion" @default.
- W2384167129 hasPublicationYear "2008" @default.
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