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- W2384168370 abstract "ObjectiveTo analyse the polymorphisms of leptin receptor gene 3057 G/A in schizophrenic inpatients with long-term antipsychotics use, and study its associations with antipsychotics-related obesity impaired glucose tolerance (IGT), type 2 diabetes mellitus (T2DM) and hypertension.Methods84 schizophrenic inpatients with long-term antipsychotics were involved in the study. Leptin receptor gene 3057 G/A polymorphisms and allele were determined with the polymerase chain reaction and restricted fragment length polymorphism assay. Serum insulin and leptin were measured with radioimmunoassay respectively. Results(1) The G→A variation of leptin receptor gene 3057 G/A in schizophrenic patients with long-term antipsychotics was 92.26%. (2) The differences of leptin receptor genotypes and allele distribution between obesity and non-obesity group were not found(~2=5.23 and 1.04)(P0.05). (3) The differences of major clinical variates and suffering from IGT, type 2 diabetes mellitus between genotype GA and AA were not found, but the serum cholesterol level in genotype AA patients were significantly close to higher than that in genotype GA[(4.74±1.01)mmol/L vs (4.18±0.71) mmol/L] (P=0.08), and systolic pressure in patients with genotype AA was significantly higher than that in patients with genotype GA[(16.4±1.98)kPa vs (15.5±0.60)kPa] (P0.05). (4) Multiple linear regression analysis suggested polymorphisms of leptin receptor gene 3057G/A did not entry the equation that influenced fasting blood glucose level.Conclusions(1) The polymorphisms of leptin receptor gene 3057G/A were not associations with antipsychotics-related obesity, IGT, and T2DM, and it had not been considered as a gene predictors that influenced obesity and blood glucose metabolism in schizophrenia. (2) Schizophrenic patients with genotype AA trend to present in elevation of systolic pressure and lipid metabolic disturbances." @default.
- W2384168370 created "2016-06-24" @default.
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- W2384168370 date "2006-01-01" @default.
- W2384168370 modified "2023-09-23" @default.
- W2384168370 title "Polymorphisms of leptin receptor gene 3057G/A associated with antipsychotics-related obesity and hypertension" @default.
- W2384168370 hasPublicationYear "2006" @default.
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