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- W2384175280 abstract "To study the effect of combination of half dose of reversal agents on multi-drug resistant leukemia cells. The reverse role of cyclosporin A(CsA), tamoxifen (TAM) and interferon-α(IFN-α) in a multi-drug resistant leukemia cell line(P388/VCR) were detected by MTT method and flow cytometer. Multi-drug resistance can partially reversed by addition of CsA, TAM, and IFN-α, their effect could be ordered as CsA IFN-αTAM. Half dose of CsA combined with half dose of TAM and IFN-α had more stronger reversal effect than that of the full dose of TAM or IFN-α alone, but the reversal effect was weaker than that of full dose of CsA. [Conclusions] CsA, TAM or IFN-α have obvious reversal effects on the MDR in leukemic cell line. The combination of half dose of CsA and TAM and/or IFN-α may be more favored for patients with leukemia MDR." @default.
- W2384175280 created "2016-06-24" @default.
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- W2384175280 date "2004-01-01" @default.
- W2384175280 modified "2023-09-24" @default.
- W2384175280 title "Reversal Effect of Half Dose of Three Reveral Agents on Multi-drug Resistant Leukemia" @default.
- W2384175280 hasPublicationYear "2004" @default.
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