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- W2384175999 abstract "Objective To evaluate the relationship between the insertion/deletion(I/D) polymorphism in the AngiotensinⅠ-converting enzyme(ACE) gene and risk of progression of diabetic nephropathy(DN) among healthy Han ethnic group in China,by performing a meta-analysis.Methods Two reviewers independently searched the CNKI,CBM,VIP,and Wanfang databases from 1994 to May 30,2012,only case-control studies of ACE I/D polymorphism and DN among healthy Han ethnic group in China were included.After extracted the data of the included studies,a meta-analysis was performed by using Meta-Analyst 3.13 software.Results Twenty-five case-control studies involving 1 670 DN patients met the criteria.Meta-analysis results showed that the healthy subjects among the Chinese Han ethnic group with the genotype containing D allele would obviously increase the risk of progression of DN.The sensitivity analysis showed all the results were robust.Conclusion ACE I/D polymorphism is significantly associated with susceptibility to DN in the healthy Chinese Han ethnic group.The D allele may be the susceptibility gene,while I allele may be the protection gene,but further studies are suggested." @default.
- W2384175999 created "2016-06-24" @default.
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- W2384175999 date "2012-01-01" @default.
- W2384175999 modified "2023-09-23" @default.
- W2384175999 title "Meta-analysis of Association between AngiotensinI-converting Enzyme Gene Insertion/deletion Polymorphism and Risk of Progression of Diabetic Nephropathy among Healthy Han Ethnic Group in China" @default.
- W2384175999 hasPublicationYear "2012" @default.
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