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- W2384184148 abstract "Objective To probe the expression of pro-inflammatory cytokines (interleukin-6,tumor necrosis factor -α) and anti-inflammatory cytokine (interleukin-4) in the degenerative discs and its clinical significance.Methods Specimens of nucleus pulposus from 30 cases of disc herniation in single level and 10 cases of scoliosis following anterior release were harvested.The degree of clinical symptoms in all cases was evaluated by Oswestry disability index and the degree of the disc degeneration in MRI was assesed by Schneiderman's classification.The contents of interleukin-6,tumor necrosis factor-αand interleukin-4 were detected by enzyme-linked immunosorbent assay.Results The expression levels of interleukin-6 (11.2± 7.5) and tumor necrosis factor-α (186.8± 86.0) were significantly higher in the patients than in the controls (6.4± 0.8 and 122.3± 23.5 respectively).There was a positive correlation between the co-expression of interleukin-6 and tumor necrosis factor-αand ODI evaluation (IL-6:B= 0.481,β= 0.229, P 0.05;TNF-α:B= 6.945E-2,β= 0.522, P 0.01).Interleukin-4 only existed in the case of high concentration of tumor necrosis factor-α.There was no relationship between the MRI grades and the expression of cytokines.Conclusion The high expression of pro-inflammatory cytokines,such as interleukin-6 and tumor necrosis factor-α,is one of the important reasons for disc degeneration and related to the clinical symptoms.The unbalance between the expression of pro-inflammatory and anti-inflammatory cytokines may be one of the important reasons for disc degenerations." @default.
- W2384184148 created "2016-06-24" @default.
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- W2384184148 date "2006-01-01" @default.
- W2384184148 modified "2023-09-23" @default.
- W2384184148 title "The expression of pro-inflammatory and anti-inflammatory cytokines in the degenerative discs and its clinical significance" @default.
- W2384184148 hasPublicationYear "2006" @default.
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