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- W2384185488 abstract "Objective To evaluate the usefulness of apparent diffusion coefficient (ADC) in estimating tumor necrosis after transarterial chemoembolization (TACE).Methods (1)24 adult male New Zealand White rabbits were selected, the VX2 tumor cells were implanted into the left lobe of the liver, and established the implanted model of hepatic carcinoma. (2) 2 weeks later, 24 rabbits bearing VX2 tumors successfully underwent conventional MRI and DWI examination. Both conventional images and DWI were obtained with a 1.5T MR imaging system(Signa Infinity Twinspeed Excite, GE, US) and a phased array knee coil. The DWI protocol was SE-EPI (TR/TE=3000～4000 ms/50.9～70.2 ms; slice thickness, 3 mm; interslice gap , 0.5 mm; FOV ,12×12 cm; b-factors , 600 s/mm~2). (3)All 24 rabbits bearing VX2 tumors in the livers were divided randomly into two groups: A, TACE group and B,control group. A group underwent TACE using the mixture of ethiodized oil and Adriamycin; while B group was untreated.(4)3 days after treatment, both A、B groups performed MRI study using the same ways as (2).3 ROIs were placed diffusedly in the tumor and the mean ADC value was measured.(5)After MRI scan, all animals were sacrificed and the livers were dissected and sliced. The percentage of necrotic area in each rabbit was calculated, and the relationship between ADC of A、B groups and extent of necrosis was analyzed by a Pearson’s correlation test. Results 24 rabbits (100%)were implanted successfully, and the tumors were 1～2 cm in diameter 2 weeks later. There was a significant difference in the ADCs between TACE group and control group by (1.92±0.19 )×10~ -3 mm~2/s vs (1.63±0.12)×10~ -3 mm~2/s; the tumor necrotic percentage was in 89.1±0.4% in TACE group while 46.6±0.5% in the control group.A significant positive correlation between ADC and tumor necrosis was noted.Conclusion The ADC value correlates well with tumor necrosis, it has potentiasl for detecting early response of tumor to TACE." @default.
- W2384185488 created "2016-06-24" @default.
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- W2384185488 date "2006-01-01" @default.
- W2384185488 modified "2023-09-26" @default.
- W2384185488 title "Value of apparent diffusion coefficient in monitoring tumor response to TACE of hepatic carcinoma in rabbits" @default.
- W2384185488 hasPublicationYear "2006" @default.
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