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- W2384191808 abstract "Aim To investigate the change of intestinal permeability in different NSAIDs enteropathy models.Methods NSAIDs enteropathy models were induced by different NSAIDs(aspirin,indomethacin,diclofenac).Aspirin group(500 mg·kg-1),indomethacin group(5 mg·kg-1),diclofenac group(10 mg·kg-1) were administered by gavage for 3 days.Diclofenac was administered orally at different times and doses.Evans-blue permeability test was detected in the small intestine of mice at the end of experiment,and the number of ulcers was calculated.Results In the different NSAIDs enteropathy models,the aspirin group did not have any ulceration,the small intestinal permeability slightly elevated(621.1 ± 114.2 vs 460.6 ± 89.7 μg·g-1).Indomethacin significantly induced the small intestinal damage in mice,which showed an significantly increased ulcers(8.2 ± 1.9 vs 0) and higher intestinal permeability(2 132.0 ± 315.7 vs 460.6 ± 89.7 μg·g-1).Compared with indomethacin group,the small intestinal mucosal injury and intestinal mucosa permeability were reduced in diclofenac group.The small intestinal damage and permeability turned to be more apparent with the doses and times increased.Conclusion In different NSAIDs enteropathy models,aspirin induced a slight damage,while the severe intestinal damage were seen in indomethacin group.Diclofenac 2.5 mg·kg-1 orally three days can cause increased small intestinal permeability and intestinal damage,which is suitable for the study of NSAIDs enteropathy model." @default.
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- W2384191808 date "2011-01-01" @default.
- W2384191808 modified "2023-09-26" @default.
- W2384191808 title "The change of intestinal permeability in different NSAIDs enteropathy models" @default.
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