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- W2384192889 abstract "AIM: To study the bioequivalence of two ondansetron hydrochloride tablets in Chinese healthy volunteers. METHODS: A randomized crossover study designing was adopted in the study.20 healthy volunteers were given single oral dose of ondansetron(8 mg).The concentration of ondansetron in plasma was measured by HPLC-MS.All statistic analysis was performed by using SPSS 13.0 statistics software.RESULTS:The pharmacokinetic parameters of the test and reference preparation were as follow: Cmax were(33±8) and(32±8) μg/L,tmax were(1.5±0.3) and(1.5±0.4) h,AUC0~24 were(176±67) and(168±58) μg·h·L-1,AUC0~∞ were(188±70) and(182±63) μg·h·L-1.The relative bioavailability of the test was(103.2±10.0) %.CONCLUSION: The two ondansetron hydrochloride tablets are bioequivalent." @default.
- W2384192889 created "2016-06-24" @default.
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- W2384192889 date "2011-01-01" @default.
- W2384192889 modified "2023-09-23" @default.
- W2384192889 title "Bioequivalence of ondansetron hydrochloride tablets in healthy volunteers" @default.
- W2384192889 hasPublicationYear "2011" @default.
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