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- W2384198108 abstract "AIM To prepare felodipine/metoprolol transdermal patch and to evaluate its percutaneous permeability through in vitro excised rabbits skin and irritation to rabbits skin.METHODS The permeating rate of drugs from the patch was determined by modified Franz diffusion cells method.Excised rabbits skin were used as permeation barriers,physiological saline-alcohol(60∶40) was used as receptor and the concentration of felodipine and metoprolol in skin diffuse solution was measured by RP-HPLC simultaneously.The irritation of the patch to skin was assessed by rabbits skin irritation test.RESULTS The penetration of felodipine and metoprolol in the patch through in vitro excised rabbits skin both followed zero-order dynamics in 48 h synchronously.There was no significant irritation to rabbits skin.CONCLUSION It is evident that the felodipine/metoprolol transdermal patch has good controlled release properties,in vitro stable percutaneous permeability and less irritation to skin which accords with the demands of transdermal drug delivery system." @default.
- W2384198108 created "2016-06-24" @default.
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- W2384198108 date "2008-01-01" @default.
- W2384198108 modified "2023-09-22" @default.
- W2384198108 title "In vitro percutaneous permeability of felodipine/metoprolol transdermal patch in excised rabbits skin and irritation to skin" @default.
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