Matches in SemOpenAlex for { <https://semopenalex.org/work/W2384221997> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2384221997 abstract "Objective To study the effect of paclitaxel on mTOR signaling pathway in NSCLC cell A549 and the combination effects of paclitaxel and mTOR inhibitor Rapamycin.Methods Cell cycle and apoptosis were detected by flow cytometry after cells treated by paclitaxel with or without Rapamycin.The expression or phosphorylation of cell signaling molecules were determinated by Western blot,and inhibition rate of tumor cell proliferation was detected by cell counting.Results The apoptosis rate of A549 treated by 5×10~(-6)g/L paclitaxel for 24 hours was(31.26±2.52)%.The apoptosis induction effect of higher concentration of paclitaxel decreased,but the cell mitosis blocking effect increased with the concentration.Paclitaxel did not affect the expression of mTOR,but the expression of two molecules bounded with mTOR,raptor and rictor was up-regulated by paclitaxel. Paclitaxel could also increase the mount of survivin and the phosphorylation of S6K1.The apoptosis inducing effect and the antitumor effect of paclitaxel were enhanced by Rapamycin which adding in the cell culture medium with paclitaxel simuteniusly or after the pretreatment for 16 hours.Conclusion Paclitaxel activates mTOR associated pathway.Inhibition of mTOR with Rapamycin can enhance the anti-tumor effect of paclitaxel,and promote the apoptosis induced by palitaxel." @default.
- W2384221997 created "2016-06-24" @default.
- W2384221997 creator A5038805449 @default.
- W2384221997 date "2010-01-01" @default.
- W2384221997 modified "2023-09-28" @default.
- W2384221997 title "Inhibition of paclitaxel combined with mTOR inhibitor Rapamycin on proliferation of NSCLC cells" @default.
- W2384221997 hasPublicationYear "2010" @default.
- W2384221997 type Work @default.
- W2384221997 sameAs 2384221997 @default.
- W2384221997 citedByCount "0" @default.
- W2384221997 crossrefType "journal-article" @default.
- W2384221997 hasAuthorship W2384221997A5038805449 @default.
- W2384221997 hasConcept C104202773 @default.
- W2384221997 hasConcept C1491633281 @default.
- W2384221997 hasConcept C153911025 @default.
- W2384221997 hasConcept C185592680 @default.
- W2384221997 hasConcept C190283241 @default.
- W2384221997 hasConcept C2775975398 @default.
- W2384221997 hasConcept C2776694085 @default.
- W2384221997 hasConcept C2777292972 @default.
- W2384221997 hasConcept C29537977 @default.
- W2384221997 hasConcept C43060935 @default.
- W2384221997 hasConcept C502942594 @default.
- W2384221997 hasConcept C54355233 @default.
- W2384221997 hasConcept C553184892 @default.
- W2384221997 hasConcept C55493867 @default.
- W2384221997 hasConcept C62112901 @default.
- W2384221997 hasConcept C81729549 @default.
- W2384221997 hasConcept C86554907 @default.
- W2384221997 hasConcept C86803240 @default.
- W2384221997 hasConceptScore W2384221997C104202773 @default.
- W2384221997 hasConceptScore W2384221997C1491633281 @default.
- W2384221997 hasConceptScore W2384221997C153911025 @default.
- W2384221997 hasConceptScore W2384221997C185592680 @default.
- W2384221997 hasConceptScore W2384221997C190283241 @default.
- W2384221997 hasConceptScore W2384221997C2775975398 @default.
- W2384221997 hasConceptScore W2384221997C2776694085 @default.
- W2384221997 hasConceptScore W2384221997C2777292972 @default.
- W2384221997 hasConceptScore W2384221997C29537977 @default.
- W2384221997 hasConceptScore W2384221997C43060935 @default.
- W2384221997 hasConceptScore W2384221997C502942594 @default.
- W2384221997 hasConceptScore W2384221997C54355233 @default.
- W2384221997 hasConceptScore W2384221997C553184892 @default.
- W2384221997 hasConceptScore W2384221997C55493867 @default.
- W2384221997 hasConceptScore W2384221997C62112901 @default.
- W2384221997 hasConceptScore W2384221997C81729549 @default.
- W2384221997 hasConceptScore W2384221997C86554907 @default.
- W2384221997 hasConceptScore W2384221997C86803240 @default.
- W2384221997 hasOpenAccess W2384221997 @default.
- W2384221997 hasRelatedWork W1867502355 @default.
- W2384221997 hasRelatedWork W1984034991 @default.
- W2384221997 hasRelatedWork W2039481576 @default.
- W2384221997 hasRelatedWork W2077013844 @default.
- W2384221997 hasRelatedWork W2078692598 @default.
- W2384221997 hasRelatedWork W2126614028 @default.
- W2384221997 hasRelatedWork W2167749003 @default.
- W2384221997 hasRelatedWork W2258933386 @default.
- W2384221997 hasRelatedWork W2355422040 @default.
- W2384221997 hasRelatedWork W2357794405 @default.
- W2384221997 hasRelatedWork W2359293971 @default.
- W2384221997 hasRelatedWork W2366850648 @default.
- W2384221997 hasRelatedWork W2372793915 @default.
- W2384221997 hasRelatedWork W2383132248 @default.
- W2384221997 hasRelatedWork W2395307434 @default.
- W2384221997 hasRelatedWork W2398421106 @default.
- W2384221997 hasRelatedWork W2518068958 @default.
- W2384221997 hasRelatedWork W2883453948 @default.
- W2384221997 hasRelatedWork W2958592462 @default.
- W2384221997 hasRelatedWork W3003328300 @default.
- W2384221997 isParatext "false" @default.
- W2384221997 isRetracted "false" @default.
- W2384221997 magId "2384221997" @default.
- W2384221997 workType "article" @default.