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- W2384222364 abstract "Objective To compare the serum protein -bindin g rate of Qingxintong in non -pregnan t women,early Preg-nant women and late Pregnant women.Methods The protein -binding rate of Qingxin tong was estimated by protein equili-bration dialyzator and was determin ed by HPLC.Results The protein binding rate of Qingxint ong was(73.69±10.96)%,(73.17±9.31)%and(60.93±7.06)%in non -pregnant women,early Pregn ant women and late Pregnant women respectively.The binding rate of Qingxintong with 1%albumin was(42.96±17.57)%.The association constant in equilibrium was 1.477×10 -3 mol /L,and the binding site was 0.17.The maximum binding power of drug -albumin complex in non -pregnant women,early Pregnant women and late Pregnant wo men was 3.69μmol /g,5.34μmol /g and2.14μmol /g respectively,and the dissociation constant of the complex was 27.36μmol /g,27.87μmol /g and 12.37μmol /g respectively.Conclusion Qingxintong binds with serum albumi n chiefly.The significant differen ce of protein binding rate and parameters in early and late Pregnant women is correlate d to the serum protein level." @default.
- W2384222364 created "2016-06-24" @default.
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- W2384222364 date "2003-01-01" @default.
- W2384222364 modified "2023-09-25" @default.
- W2384222364 title "Serum Protein -binding Rate of Qingx ingtong in Pregnant Women" @default.
- W2384222364 hasPublicationYear "2003" @default.
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