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- W2384229175 abstract "Objective To investigate the mechanism by which mGluR5 activation suppress the inflammation induced by activated microglia.Methods The effect of(RS)-2-chloro-5-hydroxyphenylglycine(CHPG) on LPS4 nduced inflammation,the expression of mGluR5 and its downstream MAPK signaling pathways were detected with Griess test,enzyme-linked immunosorbent assay,western blot and flowcytometry.Results CHPGreversed LPS-induced decrease of mGluR5(P = 0.0003) and p-JNK expression(P = 0.005) and no such effect of CHPGwas observed in mGluR5 knockdown cells(P = 0.4694,P = 0.4407).Conclusion The anti-inflammation effect of mGluR5 activation is mediated by raising the expression of mGluR5 and its downstream JNK signaling pathway." @default.
- W2384229175 created "2016-06-24" @default.
- W2384229175 creator A5020059398 @default.
- W2384229175 date "2015-01-01" @default.
- W2384229175 modified "2023-09-23" @default.
- W2384229175 title "CHPGprotects against LPS-induced inflammation by modulating mGluR5 and JNK signaling pathway" @default.
- W2384229175 hasPublicationYear "2015" @default.
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