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- W2384230982 abstract "Aim Investigate the effects of L-Arg during blood-stage infection by P.y17XL in BALB/c mice.Methods Mice were orally administrated with L-Arg(1.5 g·kg-1) 7 days before P.y17XL infection(L-Arg group).The control group received the same volume normal saline at the same time points before P.y17XL infection.Parasitemia were monitored by Giem-sa stained thin-smear microscopy.Flow cytometry was introduced to detect the subsets of splenic CD4+CD 69+T,F4/80+CD36+macrophages on day 3,5 post infection(pi).The level of IFN-γand NO in the supernatant of splenocytes culture was detected by ELISA and Griess reaction,respectively.Results Pretreatment of mice with L-Arg significantly decreased the parasitemia and elongated their survival time after infection.The number of F4/80+CD36+macrophages and CD4+CD69+T cells was obviously higher in L-Arg group.Enhanced IFN-γand NO pro-duction induced by L-Arg in spleen cells of infected mice revealed that the Th1 immune response was stimulated against malaria infection.Conclusion L-Arg can induce protective Th1 immune responses to control the proliferation of malaria parasites during the blood-stage of P.y17XL infection." @default.
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- W2384230982 date "2011-01-01" @default.
- W2384230982 modified "2023-09-28" @default.
- W2384230982 title "L-Arg mediated anti-malaria protectiveimmunity by enhancing Th1 immune responses" @default.
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