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- W2384233483 abstract "Objective:To investigate the relationship between the level of serum maleic dialdehyde(MDA),superoxide dismutase(SOD)and reduced glutathione(GSH)with complication of type 2 diabetic mellitus.Methods:One hundred and fifty patients with type 2 diabetes mellitus were divided into three groups,patients with normal albuminuria,microalbuminuria and clinical proteinuria group(n = 50 for each group),50 healthy persons were as control group.The level of serum homocysteine(Hcy) was detected by ELISA assay.The levels of serum SOD,GSH and MDA were detected by spectrophotometer.Results:The serum levels of Hcy and MDA were significantly higher in patients with diabetes than those of normal control group(P 0.01),and significantly higher in micro-albuminuria albuminuria group and clinical group than those of normal albuminuria group(P 0.01).The levels of SOD and GSH were significantly lower in patients with diabetes than those of normal control group(P 0.01),and significantly lower in micro-albuminuria albuminuria group and clinical albuminuria group than those of normal control group(P 0.01).The serum levels of SOD and GSH were significantly lower in Hcy15 μmol/L group than those of Hcy≤15 μmol/L group(P 0.01).The serum level of Hcy was positively correlated with the serum level of MDA(r = 0.64,P 0.01) and negative correlated with SOD and GSH(r =-0.57 and r =-0.62,P 0.01).Conclusion:The serum homocysteine involved in the development and procession of diabetic nephropathy via damaged oxidative stress." @default.
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- W2384233483 date "2010-01-01" @default.
- W2384233483 modified "2023-09-22" @default.
- W2384233483 title "The Relationship between the Serum Homocysteine and Oxidative Stress in Patients with Diabetic Nephropathy" @default.
- W2384233483 hasPublicationYear "2010" @default.
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