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- W2384234439 abstract "In order to investigate the toxic effect of nitrobenzene on brain in mice,the mice were exposed to nitrobenzene by way of intragastric administration once per day for 30 days.The doses were 26mg/kg,52mg/kg and 105mg/kg according to the body weight of mice,respectively.The mice were sacrificed on day 2 post-final-administration.The murine brains were collected for the detection of antioxidant indexes,including activities of SOD and GSH-Px and content of MDA,and for the observation of microstructure and ultrastructure.The toxic effect of nitrobenzene on the brain in mice was apparent.The gap between blood vessels in cerebrum was enlarged in cerebrum and the peripheral nerve fibers were rarefaction under the microscope.Karyopyknosis and karyolysis of Purkinje cells and karyopyknosis of the pyra-midal cell appeared in cerebellum and hippocampus under the microscope.Under the electron microscope,the nerve cell and mitochondria swelled,the rough endoplasmic reticulum expanded,the electron density of most glial cells increased,the nuclei became smaller and appeared karyopyknosis,the organelle of the intracytoplasm obviously decreased,some nerve fibers demyelinated,and the demyelinate dissolved.With the increase of the dose of nitrobenzene,MDA content gradually increased,and CAT and SOD activities gradually decreased.The antioxidant indexes were significantly or extremely significantly different between the treatment and control groups.The results indicated that a certain dose of nitrobenzene could cause the damage of the brain through the oxidative stress and apoptosis." @default.
- W2384234439 created "2016-06-24" @default.
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- W2384234439 date "2008-01-01" @default.
- W2384234439 modified "2023-09-26" @default.
- W2384234439 title "Toxic effect of nitrobenzene on murine brain" @default.
- W2384234439 hasPublicationYear "2008" @default.
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